Good Seat At The Bob Carr

KYTHERA presents the first positive data for ATX-101

KYTHERA Biopharmaceuticals, Inc. (KYTHERA) presented the first results of the third phase II clinical study with ATX-101, the first official fat-dissolving substance that is currently in development for the reduction of submental fat pad. The phase IIb study showed that ATX-101 was well tolerated and had a statistically significant effect on the reduction of submental fat pad.

Patricia S. Walker, KYTHERAs medical director, presented the first results of phase II clinical study occasion of the 9th annual South Beach Symposium ™ in Miami.

For the study 129 people were integrated in a double-blind, placebo-controlled and randomized dose-finding study. Implemented the treatments in 10 centers for dermatology and plastic surgery have been distributed throughout the United States. Study participants received monthly over a period of up to five months in one of two doses of ATX-101 (1 mg or 2 mg per square centimeter per square centimeter) or a placebo in the submental region. A clinical assessment of the situation was made before any treatment and four, or 12 weeks after the last treatment. An exact evaluation of the submental region by magnetic resonance imaging (MRI) was performed after pre-treatment, the fifth treatment and 12 weeks after the last treatment. In addition, the study participants had also a self-assessment using a questionnaire at the beginning, during and after the release treatment.

The data the trial showed that the regimen mg 2 per square centimeter was better in terms of the reduction of submental fat pad than when only 1 mg ATX was injected 101 per square centimeter, indicating a dose-dependent effect Close by ATX-101 can.

"The results of the study are very encouraging and demonstrate the potential of ATX-101 as an effective and well acceptable treatment plan for the aesthetic correction of small fat deposits, "said Joel Schlesinger, one of the attending physicians. "There is currently no FDA (Food and Drug Administration ) approved non-surgical method for reduction of localized fat deposits under the chin. ATX-101 could therefore be a breakthrough for patients who prefer a minimally invasive therapy for reduction of submental fat pad. "

The evaluation of the data was based on structured questionnaires, which treated both by physicians and by the Study participants were completed. In addition, the submental Region by MRI in fat content were examined.

"The results are very encouraging for us," said Patricia Walker. "We could show in three phase II studies an important and statistically significant reduction of submental fat pad. We are confident that our new data with the data from other Phase II studies will allow to take the next step in the direction phase III studies that we should then confirm definitively that ATX -101 both safe and effective. "

presented in the study was ATX-101 of the participants well tolerated. The most common side effect was mild swelling, pain, numbness, bruising and induration. Side effects were limited to the injection site and usually disappeared within the 28-day interval. Side effects that would have the rest of the body based, were not found.

addition to the results that have already been shown in Miami are, on the 35th Hawaii Dermatology Seminar ™ are presented by next March in Maui. Should also be taken together all the results and published in a journal.

About ATX-101

ATX-101 is the first official Drug that was developed exclusively for the reduction of small fat deposits. ATX-101 is based on a well-studied endogenous molecule with very specific properties, such as a high selectivity for fat cells and a rapid rate of degradation. The injection of ATX-101 is a minimally invasive procedure that requires little or no anesthesia and could still show clinically significant results. Clinical studies with ATX-101 have been able to confirm the expected results. Accordingly, ATX-101 is safe, well tolerated and effective. Three randomized, double-blind placebo-controlled phase II studies for reduction of submental fat and two phase I pharmacokinetic and histological studies have already been carried out successfully.

About submental fat (SMF)

The submental fat is a localized fat deposits that are located directly below the chin and jaw line. In the fast-growing market for minimally invasive, non-surgical facial rejuvenation is the reduction of submental fat pad to restore a straight jawline one of the greatest unsolved problems. In a recent multicenter study with more than 385 persons for treatment with botulinum toxin or a dermal filler had imagined could be found in 78% of the sample an excess submental fat. There are currently no drugs approved by any health authorities for the reduction of localized fat .

Source: swissestetix Blog

«i-catcher Console - Web Monitor»

Internet: secret societies promote eating disorders

It can be a hopeless and heart-wrenching situation for a family if she tries one of its members with the fact confronting an eating disorder. What they sense at a time like hardly is that the internet is a close-knit community that torpedoed all attempts at normalization of the disorder.

report communication researchers at the University of Cincinnati by an alarming new phenomenon that spreads within social groups on the Internet, support groups for eating disorders. This new form of negative social networks (the authors call them Online Negative Enabling Support Group [ONESG] ) primarily serve the purpose of its members hold to speak with the rod and against all attempts of the environment, to relieve them of their disease, to immunize.

Society members consider their condition, specifically those of anorexia, as an option rather than as a disease. The pro-anorexia ONESG Motion covers four major topics of the disease and used various communication strategies to anorexics to convince them to acknowledge their dangerous and harmful impulses, writes Stephen M. Haas, lead author of the study , in the journal New Media & Society has been released.

The four themes that focused the ONESG are

1) remain The anorexia movement loyal to Forums and blogs invite the members of a do on issues such as food, down loops (" binging ") and endurance training to discuss. There is also something like an "online confessional" where members can confess if they have eaten too much or not enough driven sport to meet the "guidelines" of the community.

2) support of strategies for self-contempt: The websites of the community encourage input, the contents reflect not only contempt for his own body, but should bring in addition also the writer to himself and his inner self to be regarded as worthless and weak. Negative of such communication is acknowledged by the other visitors to the site with positive reactions - a behavior which according to the authors of the study is found only in support groups for eating disorders. The embassies of the members of the other members approved expressly provided in any case in question. This is among the visitors to the site a common identity in the recognition of the common weaknesses and mistakes.

3) Pro-anorexia support: In most cases these forms support is to make the member of the Community assistance in regard to dietary issues and how to deal with outsiders who are trying to confront a member with his condition and to move away from the anorexia of . Move

4) encouraging anorexia: encouragement is the fourth communication strategy that the authors could make within this group . This can by sympathetic messages, which are designed to strengthen the sense of going over tips and tricks anorexic behavior to explicit defense strategies against the negative attitude of non-anorexics.

were in the statements of ONESG group determine the researchers a general ambivalence between self-loathing and Selbstaufmunterung. "When the ambivalence between self-loathing and Selbstaufmunterung to accept part of anorexia is an important strategy within the group because it reveals the inner turmoil in anorexics, "the authors write. is "anorectics cling relentlessly at the idea that achieving a certain weight loss could free them from their inner feelings of worthlessness and undesirability, but that the ways and means by which they could get this feeling of belonging stigmatized and labeled as undesirable. "The

researchers say that such secret social networks are by the anonymity of the Internet, in the extreme opinions on their space, to be strengthened. The exchange makes it possible to deal with potentially dangerous, negative behavior patterns and incorporate them into his own behavior, and new, for the members to create positive behavior patterns. Caring embassies prepare the ground for it by forming a strong sense of community.

The authors write that with the emergence of new social media means of communication, understanding the role of ONESGs more important. They add that the understanding of such communication strategies can help in an emergency to break the typical defensive behavior in potentially life-saving measures.

The researchers have collected their data on social networking sites and specific pro-anorexia sites, their access was public. The Web sites and blogs have been tracked and analyzed 2006-2007. The blog and Fourmsbeiträge came, as far as eruierbar, from women aged 13 26

Source: swissestetix Blog

Material List For Swing Sets

influence of BMI on the risk of death in Asia

A large study with over one million Asians showed that normal weight had a much lower overall risk of death than those whose Body Mass Index (BMI) either was too high or too low. A similar relationship was also for the relationship between BMI and risk of death from cancer, heart cardiovascular disease and other causes are found. This data support the Asian a recent American study , which had investigated almost 1.5 million people on these facts out.

The study , the largest Asian study this type was, by Wei Zheng, professor of cancer research at the Vanderbilt-Ingram Cancer Center in Nashville, Paolo Boffetta of the Mount Sinai School of Medicine in New York and John D. Potter of the Public Health Sciences Division of the Fred Hutchinson passed Cancer Research Center in Seattle. She is in the latest issue of the journal New England Journal of Medicine (NEJM) published .

"All prior studies that examines the relationship between BMI and mortality risk have , are based primarily on data by Europeans or descendants of Europeans. Indeed at the moment is based valid definition of normal and overweight on the derived from these studies criteria, "Zhen said their motivation to study . "The validity of these criteria for the Asian population has provided yet be. A large majority of Asians are very slim, and the influence of a very low BMI on the risk of death has so far not been studied in this population. "

The World Health Organization (WHO) estimates that more than one billion people worldwide are overweight and at least 300 million are obese. From the fat white one for some time, that there is an active endocrine organ that can deliver a number of biologically active substances in the blood that contribute to the development of obesity-related diseases. Typically include adult-onset diabetes (type 2 diabetes), high blood pressure, coronary heart disease, stroke and a number to cancer.

The study is part of the Asia Cohort Consortium investigation. This health reports and death information from more than 1.1 million individuals from East and South Asia have been sighted. In the group of East Asians, which include the Chinese, Japanese and Koreans, the lowest risk of death for people with a BMI of 06/22 to 05/27 was determined what would generally be defined as normal to slightly overweight.

distinguished general, the Chinese, Japanese and Koreans hardly different from similar groups in the world population. For those with a BMI 35 or more was the risk of death by a whopping 50% increased, so did not demonstrate in the Indian and Bangladeshi population. This could be an indication that a high BMI does not lead in all ethnic groups to the same consequences.

severely underweight in the Asian population was far worse than obesity. The mortality risk was increased by a factor of 2.8, when the BMI fell below the value 15. A BMI value of 15 also applies to Caucasians as extremely underweight, but not the same strong increase in the death-risk result.

"The most surprising finding was that obesity (obesity ) on the Indian subcontinent, not with a dramatic increase in risk of death, was connected, "said Potter. "This could be due to the fact that overweight or obese people have on the Indian subcontinent usually have a higher socio-economic status and thus can afford better medical care."

"Our findings show two different aspects of a rapidly evolving pattern ; was extreme body now widespread in Asia and we can see his important influence on the probability of death is still, "Boffetta said. "If we take the future into the eye, we find that in Asia, as elsewhere, prevention of obesity highest priority must be given. "

The authors conclude from their data that their study is another strong indication that obesity leads to an increase in death risk. In this aspect, at least in Asians and Caucasians but then seem to be not so different.

Association between Body-Mass Index and Risk of Death in More Than 1 Million Asians

Source: swissestetix Blog

Write Intervention Letter

phones affect brain activity

If a cell phone during a call for a long time to the Ear has increased brain activity in regions that are closest to the antenna.

According to the investigation, which Nora Volkow and her colleagues from National Institute on Drug Abuse conducted have , increased glucose metabolism in orbitofrontal cortex and temporal significantly if a current mobile phone - was held to the ear compared to a mobile phone which was on display - though to put a sound. The results of the study were published in today's issue of the Journal of the American Medical Association (JAMA) .

"Although we are unable to determine the clinical relevance of our results may have, so we show the study quite clear that the human brain is sensitive to the effects of radio-magnetic fields of a current mobile phones," said Gene-Jack Wang, one of the co-authors of the study . And though the study provides no indication of what could be the long-term effects of such a mass change in brain activity, the results are after all, of the international research community is already considered as very important.

"There are obviously quite clearly an acute effect of radio waves and magnetic The important question now is whether this effect can be seen in any way connected with changes must be harmful to the brain or contribute to the development of future problems such as brain tumors could. Recent epidemiological studies indicate, inter alia, a cluster of brain tumors, "said Santosh Kesari, director of neuro-oncology at the University of California San Diego.

It was in the past repeatedly studies, the possible relationships between brain tumors and the use of cell phones have investigated . But so far the results have been contradictory and unconvincing.

only just was eagerly awaited by many Interphone study of the scientific community unanimously labeled as "not credible" because some of the statistical values on a significant protective effect of mobile phone use indicates. This was however not for the extreme-phone users (who had an increased risk for the development of a glioma), whose phone use, however, considered unrealistic and was not representative.

Few researchers have but examines the actual physiological effects of radio frequency waves and electromagnetic fields emitted by devices on the brain. Some have shown that blood flow is increased in certain brain regions, when the phone is in use. are works on the effect of mobile phones on the neuronal activity, however it is not practical.

Volkow and her colleagues have for this purpose, a study conducted had to lie down in the 47 patients with a phone to each ear for 50 minutes in a PET scanner . The researchers examined in the wake of the glucose metabolism of the brain once made with the mobile phone right but silently and once issued with both phones.

treats it with the metabolism of the entire brain, they could no difference recognize and flared between cell phone use. They investigated only the regions that were closest to the antenna, the orbitofrontal cortex and the temporal lobes, they found a significant difference in glucose metabolism, when the phone was made.

calculations could confirm that the regions in which the radio frequency and electromagnetic fields from mobile phone use were strongest, in fact identical to those that showed the greatest increase in glucose metabolism.

"Although the radio frequency waves emitted by mobile phones today are weak, they can apparently enable the brain to the extent that it leads to a measurable effect, "Volkow said in a JAMA Report Video.

The differences in neuronal activity could be to changes in neurotransmitter release, are the permeability of the cell membrane, the excitability of neurons or the calcium efflux from the cell due.

It was also considered whether the heat emanating from a current cell phone for the functional changes in the brain may be responsible. The researchers hold this theory but probably for less.

Wang noted that the impact of study are unclear: "There are other studies needed to determine if the effects we have observed that, have potentially long-term consequences could, "he said. A new study this is not yet planned.

"The take-home message," said Kesari, "is that we still know too little, that more studies are necessary and that the mobile phone user should try in the meantime, whenever it goes to the earphone use and reduce the use of cell phones as much as possible - should this even be possible. The use of mobile phones in children only conditionally admit is certainly not unreasonable in this situation. "

Source: could swissestetix Blog